Psychiatric disorders and hepatitis C treated with direct-acting antivirals in a French reference center

HCV can cause psychiatric disorders. It is crucial to re-evaluate them with direct-acting antiviral treatment (DDAs), since the interferon-based treatments of past were capable causing identical adverse effects. A system multidisciplinary team (MDT) meetings was implemented in France December 2014 regional reference centers aim controlling prescription and administration these new treatments, along optimizing how patients undergoing are followed up. Our study sought compare characteristics type medical care received for chronic hepatitis C (PSY+ group) without (PSY- disorders using data from MDT Alsace area collected 2015 2019. All included mono-infected treated DAAs successive rounds between 2019, as per recommendations French Hepatology Society. We compared two groups PSY-) based on 21 variables regarding C. Psychiatric observed 15% patients. On multivariate analysis, a positive correlation found drug use (OR: 2.35; 95%CI: 1.40-3.98; p=0.001), excessive alcohol consumption 1.92; 0.98-3.69; p=0.05), smoking 1.81; 1.09-2.98; p=0.02), incidence interactions 3.94; 2.15-7.17; p <0.001). The only negative pangenotypic DAA 0.55; 0.32-0.92; p=0.02). SVR 12 98.05% PSY+ group, not significantly different that PSY- group. all, suffering primarily associated psycho-active substances, no impact rates. Lay summary antivirals use, tobacco consumption. They increase interactions. have virological healing. Highlights: monoinfection use. also other substances (alcohol tobacco). increased sustained response.